Aging Retina ( PreClinical Study)
Young (3-month-old) and aged (24-monthh-old) C57BL/6J wild-type mice were orally supplemented daily with omega-3 (171 mg EPA and 34 mg DHA) for 2 months. Treatment demonstrated significant protection of the photoreceptors and reduction in the number of lipofuscin granules in the RPE. Proteomic analysis shoed significantly greater protein exoression of myelin-related proteins (indicating a neuroprotective effect) and of glial fibrillar acidic protein (GFAP, astrocyte marker, representing an increase of an anti-oxidant effect)
Two months of ω3 supplementation (when the blood AA/EPA~1.0-1.5) in aged mice reduced lipofuscin granule formation in the retina and protected the photoreceptor layer, suggesting that EYETAS supplementation slows normal age-related retinal degeneration.
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