Autosomal dominant optic atrophy is a condition where the optic nerve gradually degenerates due to inherited genetic mutations, leading to progressive vision loss. This damage to the optic nerve can result in significant and often irreversible vision impairment as the neural tissue deteriorates. However, the survival of retinal cells can be supported with Eyetas dietary supplements. Omega-3 has been shown to enhance vision and protect retinal cells through its neuroprotective properties. The anti-inflammatory effects of Omega-3 supplementation are also evident at a cellular level, providing additional protection.
Opa1 (8-month-old) and wild-type (age-matched) mice were allocated to omega-3-treated and untreated groups. Treatment included daily oral administration of omega-3 PUFAs (172 mg EPA and 34 mg DHA) for 4 months. Omega-3 administration promoted neuroprotective effects in both RGCs and optic nerve axons via blockade of microglia (Iba-1) and astroglia (GFAP) activation, as well as through anti-apoptotic actions (bcl-2-associated X protein (bax) and caspase-3)
A study investigated the effects of increased production of Omega 3 on retinal ganglion cell survival after crush injury in adult mice. It was found that increased production of Omega 3 in mice enhanced retinal ganglion cell survival.
Omega 3 supplementation has neuroprotective effects in rats with optic neuropathy possibly through dual actions of anti-apoptosis of retinal ganglion cells as well as through Omega 3 PUFA' s anti-inflammatory action.
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