Пигментный ретинит. Палочко—колбочковая Дистрофия . Болезнь Штаргардта

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Stargardt disease (Preclinical Study)

Stargardt disease is an inherited eye condition that leads to gradual central vision loss, often beginning in childhood or adolescence. While there’s no cure, treatments can slow its progression. Eyetas is formulated to protect and repair retinal cells, offering hope for preserving vision in those affected by Stargardt disease.

Omega-3 Fatty Acids Supplementation: Therapeutic Potential in a Mouse Model of Stargardt Disease

Dialy administation with Eyetas (172 mg EPA and 34 mg DHA) for 3 months in 8-month-old ABCA4-/- mice of Stargardt disease showed signigicant protection of photoreceptors, lower protein levels of complement component 3 (C3) in isolated eyecups, as well as decreased number of lipofuscin granules and reduced of A2E (lipofuscin component) in the retinal pigment epithelium ( RPE)

Поддерживающее исследование

Red blood cell membrane and adipose tissue lipids were analysed as an indication of short-term and long-term dietary fatty acid in a family with autosomal dominant Stargatdt’s macular dystrophy. When adipose lipids were analysed, there was a significant inverse relationship between phenotypic severity and the level of eicosapentaenoic acid. When red blood cell lipids were analysed, there were significant inverse relationships between phenotypic severity and levels of eicosapentaenoic and docosahexanoic fatty acids.

The retinal outer nuclear layer is found reduced in patients with macular dystrophies. When mice models with Stargart’s disease were treated with Omega 3 the thickness of the retinal outer nuclear layer increased a considerable amount.

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