Diets rich in Omega 3 appear protective against AMD. Donor eyes with AMD and their age-matched controls were examined and their retinal lipid profiles were related with systemic biomarkers of lipid intake. The systemic Arachidonic acid/Eicosapentaenoic (AA/EPA) acid ratios correlated well with retinal AA/EPA ratios. The AMD donors had significantly higher retinal levels of AA/EPA ratio than their age-matched control, and the serum AA/EPA ratio was likewise higher relative to the age-matched controls.
In animal models with dry AMD, the retinal outer nuclear layer thickness increased and anti-inflammatory response was detected in the retinal tissues.
Fish consumption could reduce the risk of AMD. Epidemiological studies are in agreement that consumption of Omega 3 rich foods are associated with a lower risk of AMD.